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KMID : 0942820090080020202
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Journal of Korean Brain Tumor Society
2009 Volume.8 No. 2 p.202 ~ p.207
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Primary Malignant Fibrous Histiocytoma of the Brain
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Kim Dong-Cheon
Cho Joon
Cho Yo-Han
Roh Hong-Gee
Lim So-Dug
Kho Young-Cho
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Abstract
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Malignant fibrous histiocytoma(MFH) is a soft tissue sarcoma arising from the extremities and retroperitoneum in older adults. Primary intracranial MFH is extremely rare. A 29-year-old woman presented with headache showing three large masses on brain magnetic resonance image(MRI). She had undergone extended total gastrectomy with splenectomy under the diagnosis of advanced gastric cancer three years previously. Systemic positron extension tomography(PET) computed tomography(CT) scan on routine follow-up study before the first brain surgery revealed no hot spots. Three masses were totally removed at a single session. The pathology was confirmed to be typical MFH. Two months after the first brain surgery, she underwent tonsillectomy due to a rapidly growing tonsillar mass and the pathology was found out to be MFH. Postoperative neck CT with angiography for the evaluation of hypotension showed no significant finding. Except for the tonsillar mass, she had been symptom free during 10 months after the first brain surgery. Between 11th and 18th months postoperatively, multiple intracranial recurrences including metastatic lesions of the mediastinum and the spine were noticed. She died of pneumonia 20 months after the first brain surgery during salvage chemotherapy. We report a rare case of primary MFH of the brain with a past medical history of advanced gastric cancer.
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KEYWORD
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Malignant fibrous histiocytoma, Primary intracranial, Advanced gastric cancer, Recurrence, Tonsillectomy
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